Blar i forfatter "Wood, Shona Hiedi"

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    • Anti-angiogenic VEGFAxxxb transcripts are not expressed in the medio-basal hypothalamus of the seasonal sheep 

      Lomet, Didier; Piegu, Benoit; Wood, Shona Hiedi; Dardente, Hugues (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-10)
      This study investigated Vegfa expression in the pars tuberalis (PT) of the pituitary and medio-basal hypothalamus (MBH) of sheep, across seasons and reproductive states. It has recently been proposed that season impacts alternative splicing of Vegfa mRNA in the PT, which shifts the balance between angiogenic VEGFAxxx and anti-angiogenic VEGFAxxxb isoforms (with xxx the number of amino acids of the ...

    • Biological timekeeping in polar environments: lessons from terrestrial vertebrates 

      Hazlerigg, David Grey; Mizumo Tomotani, Barbara; West, Alexander Christopher; Appenroth, Daniel; Wood, Shona Hiedi (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-30)
      The polar regions receive less solar energy than anywhere else on Earth, with the greatest year-round variation in daily light exposure; this produces highly seasonal environments, with short summers and long, cold winters. Polar environments are also characterised by a reduced daily amplitude of solar illumination. This is obvious around the solstices, when the Sun remains continuously above (polar ...

    • Circadian clock mechanism driving mammalian photoperiodism 

      Wood, Shona Hiedi; Hindle, Matthew; Mizoro, Yasutaka; Cheng, Y; Saer, Ben; Miedzinska, K; Christian, Helen; Begley, Nicola; McNeilly, Judy; McNeilly, Alan; Meddle, Simone; Burt, Dave; Loudon, Andrew S.I. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-27)
      The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies support the universality of this so-called coincidence timer, but we lack understanding of the mechanisms involved. Here we show in mammals that long photoperiods ...

    • Diversified regulation of circadian clock gene expression following whole genome duplication 

      West, Alexander Christopher; Iversen, Marianne; Jørgensen, Even Hjalmar; Sandve, Simen Rød; Hazlerigg, David; Wood, Shona Hiedi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-08)
      Across taxa, circadian control of physiology and behavior arises from cell-autonomous oscillations in gene expression, governed by a networks of so-called ‘clock genes’, collectively forming transcription-translation feedback loops. In modern vertebrates, these networks contain multiple copies of clock gene family members, which arose through whole genome duplication (WGD) events during evolutionary ...

    • How can a binary switch within the pars tuberalis control seasonal timing of reproduction? 

      Wood, Shona Hiedi (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10)
      Life in seasonally changing environments is challenging. Biological systems have to not only respond directly to the environment, but also schedule life history events in anticipation of seasonal changes. The cellular and molecular basis of how these events are scheduled is unknown. Cellular decision-making processes in response to signals above certain thresholds regularly occur i.e. cellular fate ...

    • An integrative view of mammalian seasonal neuroendocrinology 

      Dardente, Hugues; Wood, Shona Hiedi; Ebling, Francis; Sáenz de Miera, Cristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-06)
      Seasonal neuroendocrine cycles that govern annual changes in reproductive activity, energy metabolism and hair growth are almost ubiquitous in mammals that have evolved at temperate and polar latitudes. Changes in nocturnal melatonin secretion regulating gene expression in the pars tuberalis (PT) of the pituitary stalk are a critical common feature in seasonal mammals. The PT sends signal(s) to the ...

    • A refined method to monitor arousal from hibernation in the European hamster 

      Fasth Markussen, Fredrik Andreas; Melum, Vebjørn Jacobsen; Bothorel, Beatrice; Hazlerigg, David; Simonneaux, Valerie; Wood, Shona Hiedi (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-07)
      <i>Background</i> - Hibernation is a physiological and behavioural adaptation that permits survival during periods of reduced food availability and extreme environmental temperatures. This is achieved through cycles of metabolic depression and reduced body temperature (torpor) and rewarming (arousal). Rewarming from torpor is achieved through the activation of brown adipose tissue (BAT) associated ...